Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL100009 | 0.85 | CAMKK2 (0.33) | JAK2JAK1TYK2JAK3AAK1 | |
| SCHEMBL16692498 | 0.79 | JAK2 (0.36) | JAK2JAK1TYK2JAK3AAK1 | |
| SCHEMBL18638759 | 0.76 | JAK2 (0.32) | JAK2JAK1TYK2JAK3AAK1 | |
| SCHEMBL100443 | 0.70 | GRM5 (0.46) | GRM4 | |
| SCHEMBL100420 | 0.70 | GRM4 (0.55) | JAK2JAK1TYK2JAK3GRM4 | |
| SCHEMBL12302796 | 0.67 | GRM4 (0.38) | JAK2GRM4 | |
| SCHEMBL21938259 | 0.65 | BRD4 (0.47) | — | |
| Trifluoroacetic Acid SCHEMBL4093301 | 0.64 | GRM4 (0.49) | JAK2JAK1TYK2JAK3GRM4 | |
| SCHEMBL100680 | 0.63 | GRM4 (0.55) | JAK2JAK1TYK2JAK3GRM4 | |
| SCHEMBL29540842 | 0.63 | GRM4 (0.55) | JAK2JAK1TYK2JAK3GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3838903-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | INCYTE HOLDINGS CORP (US) | 2023-11-22 | — | — | EP | disclosed |
| EP-2343299-B1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE CORP (US) | 2015-11-04 | — | — | EP | disclosed |
| EP-2343299-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2011-07-13 | — | — | EP | disclosed |