SCHEMBL2186305

SCHEMBL2186305

COCOc1cccc(OCBr)c1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAOB P27338 7/20 0.42
LMNA P02545 1/20 0.41
MAPK1 P28482 3/20 0.40
TSHR P16473 2/20 0.40
TP53 P04637 2/20 0.40
CYP3A4 P08684 2/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C19 P33261 1/20 0.40
ALDH1A1 P00352 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
HIF1A Q16665 1/20 0.40
APP P05067 1/20 0.39
FFAR1 O14842 1/20 0.36
FYN P06241 1/20 0.36
MTNR1A P48039 1/20 0.36
MTNR1B P49286 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1607526 0.89 MAOB (0.48) MAOBLMNAMAPK1TSHRTP53
SCHEMBL1770370 0.85 TP53 (0.50) MAOBLMNAMAPK1TSHRTP53
SCHEMBL5307452 0.83 MAOB (0.58) MAOBLMNAMAPK1TSHRCYP3A4
SCHEMBL30114007 0.83 MAOB (0.58) MAOBLMNAMAPK1TSHRCYP3A4
SCHEMBL2047854 0.83 MAOB (0.58) MAOBLMNAMAPK1TSHRCYP3A4
SCHEMBL16973792 0.82 MAPK1 (0.50) MAOBMAPK1TSHRTP53CYP3A4
SCHEMBL19617639 0.81 LMNA (0.42) MAOBLMNAMAPK1TSHRTP53
SCHEMBL7062770 0.81 MAPK1 (0.57) MAPK1TSHRTP53CYP3A4CYP1A2
SCHEMBL4401546 0.81 BCHE (0.44) MAOBALDH1A1FFAR1FYN
SCHEMBL3657469 0.80 APP (0.46) MAOBLMNAMAPK1TP53CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2342191-A1 AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE Mitsubishi Tanabe Pharma Corporation (JP) 2011-07-13 EP disclosed
WO-2010030027-A1 AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2010-03-18 WO disclosed
WO-2008140150-A1 NOVEL OCTAHYDRO-INDENO DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME FOOD SCIENCE CO., LTD. (KR) 2008-11-20 WO disclosed