Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 15/20 | 0.73 |
| ▸ | GRIN1 | Q05586 | 15/20 | 0.73 |
| ▸ | GRIN2B | Q13224 | 15/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.70 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19211503 | 0.86 | RXRA (0.68) | RXRAGRIN1GRIN2BKCNH2NOTUM | |
| SCHEMBL27430549 | 0.86 | RXRA (0.68) | RXRAGRIN1GRIN2BKCNH2NOTUM | |
| SCHEMBL19219461 | 0.85 | RXRA (1.00) | RXRAGRIN1GRIN2B | |
| SCHEMBL17502335 | 0.83 | KCNH2 (1.00) | RXRAGRIN1GRIN2BKCNH2 | |
| SCHEMBL23346078 | 0.83 | NOTUM (0.60) | RXRAGRIN1GRIN2BNOTUM | |
| SCHEMBL17502221 | 0.82 | KCNH2 (1.00) | RXRAGRIN1GRIN2BKCNH2 | |
| SCHEMBL19219445 | 0.81 | RXRA (1.00) | RXRAGRIN1GRIN2B | |
| SCHEMBL19219447 | 0.80 | RXRA (1.00) | RXRAGRIN1GRIN2B | |
| SCHEMBL19219460 | 0.79 | RXRA (1.00) | RXRAGRIN1GRIN2B | |
| SCHEMBL19219454 | 0.78 | RXRA (1.00) | RXRAGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180329-B1 | TRIAZOLES AS NR2B RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICALS INC (US) | 2020-03-18 | — | — | EP | disclosed |