Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11079233 | 0.78 | GRM5 (0.49) | GRM5POLBALKBH2EGLN1SMN1; SMN2 | |
| SCHEMBL5204921 | 0.78 | GRM5 (0.46) | GRM5POLBALKBH2EGLN1SMN1; SMN2 | |
| SCHEMBL13045111 | 0.78 | SMN1; SMN2 (0.47) | GRM5POLBALKBH2EGLN1SMN1; SMN2 | |
| SCHEMBL2550402 | 0.78 | GRM5 (0.46) | GRM5POLBALKBH2EGLN1SMN1; SMN2 | |
| SCHEMBL7152205 | 0.76 | GRM5 (0.54) | GRM5POLBALKBH2EGLN1SMN1; SMN2 | |
| SCHEMBL6450076 | 0.76 | GRM5 (0.65) | GRM5POLBALKBH2EGLN1SMN1; SMN2 | |
| SCHEMBL19119928 | 0.74 | GRM5 (0.46) | GRM5POLBHDAC8ALKBH2EGLN1 | |
| SCHEMBL28543136 | 0.74 | GRM5 (0.49) | GRM5POLBALKBH2EGLN1SMN1; SMN2 | |
| SCHEMBL28589923 | 0.74 | GRM5 (0.43) | GRM5POLBALKBH2EGLN1SMN1; SMN2 | |
| SCHEMBL21848975 | 0.74 | GRM5 (0.43) | GRM5POLBALKBH2EGLN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020065614-A1 | MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-02 | — | — | WO | disclosed |