Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 12/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13698841 | 0.88 | KDM4E (0.59) | GRIN2BKDM4EMEN1KMT2AGAA | |
| SCHEMBL24136379 | 0.85 | GRIN2B (0.63) | GRIN2BGRIN1 | |
| SCHEMBL22239314 | 0.85 | GRIN2B (0.63) | GRIN2BGRIN1 | |
| SCHEMBL11969109 | 0.81 | MEN1 (0.62) | GRIN2BKDM4EMEN1KMT2AGAA | |
| SCHEMBL26020752 | 0.80 | GRIN2B (0.45) | GRIN2BKDM4EGRIN1 | |
| SCHEMBL22239315 | 0.80 | GRIN2B (0.45) | GRIN2BKDM4EGRIN1 | |
| SCHEMBL21864454 | 0.80 | KMT2A (0.53) | GRIN2BKDM4EKMT2ACYP1A2CYP2D6 | |
| SCHEMBL26021340 | 0.78 | GRIN2B (0.40) | GRIN2BKDM4ECYP1A2CYP2D6HIF1A | |
| SCHEMBL16608329 | 0.77 | GRIN2B (1.00) | GRIN2B | |
| SCHEMBL16601136 | 0.77 | GRIN2B (1.00) | GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197868-B1 | N-ALKYLARYL-5-OXYARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B | CADENT THERAPEUTICS INC (US) | 2020-04-15 | — | — | EP | disclosed |