Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 19/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22239315 | 1.00 | GRIN2B (0.45) | GRIN2BGRIN1KDM4E | |
| SCHEMBL22239305 | 0.83 | GRIN2B (0.30) | GRIN2B | |
| SCHEMBL22239314 | 0.82 | GRIN2B (0.63) | GRIN2BGRIN1 | |
| SCHEMBL24136379 | 0.82 | GRIN2B (0.63) | GRIN2BGRIN1 | |
| SCHEMBL21864488 | 0.80 | GRIN2B (0.62) | GRIN2BGRIN1KDM4E | |
| SCHEMBL24270883 | 0.80 | GRIN2B (0.43) | GRIN2BGRIN1 | |
| SCHEMBL22239272 | 0.74 | KDM4E (0.35) | GRIN2BGRIN1KDM4E | |
| SCHEMBL22239247 | 0.72 | GRIN2B (0.47) | GRIN2BGRIN1 | |
| SCHEMBL24136357 | 0.72 | GRIN2B (0.68) | GRIN2BGRIN1 | |
| SCHEMBL26019399 | 0.72 | GRIN2B (0.68) | GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3974420-B1 | N-ALKYLARYL-5-OXYHETEROARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B | NOVARTIS AG (CH) | 2023-08-16 | — | — | EP | disclosed |