Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29835251 | 0.92 | SCN9A (0.42) | SCN9ATP53POLBGAAMEN1 | |
| SCHEMBL1094096 | 0.92 | SCN9A (0.42) | SCN9ATP53POLBGAAMEN1 | |
| SCHEMBL28548900 | 0.92 | SCN9A (0.39) | SCN9ATP53POLBMAPK1DHFR | |
| SCHEMBL29835222 | 0.90 | SCN9A (0.40) | SCN9ATP53POLBMAPK1GFER | |
| SCHEMBL21865388 | 0.90 | SCN9A (0.40) | SCN9ATP53POLBMAPK1GFER | |
| SCHEMBL20115730 | 0.89 | SCN9A (0.40) | SCN9ATP53POLBGAAMEN1 | |
| SCHEMBL29835279 | 0.89 | SCN9A (0.40) | SCN9ATP53POLBGAAMEN1 | |
| SCHEMBL20449461 | 0.89 | SCN9A (0.40) | SCN9ATP53POLBGAAMEN1 | |
| SCHEMBL30479338 | 0.89 | SCN9A (0.40) | SCN9ATP53POLBGAAMEN1 | |
| SCHEMBL9924609 | 0.88 | SCN9A (0.41) | SCN9ATP53POLBMAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110885319-B | Sulfonamide compounds as sodium channel blockers and uses thereof | 成都康弘药业集团股份有限公司 | 2022-08-12 | — | — | CN | disclosed |
| WO-2020052509-A1 | SULFONAMIDE COMPOUND SERVING AS SODIUM CHANNEL BLOCKER AND USES THEREOF | 成都康弘药业集团股份有限公司 | 2020-03-19 | — | — | WO | disclosed |