Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21865774 | 1.00 | MAPT (0.41) | MAPTALDH1A1HTTPOLBKMT2A | |
| SCHEMBL12904154 | 0.87 | MAPT (0.41) | MAPTALDH1A1 | |
| SCHEMBL17929007 | 0.84 | MAPT (0.37) | MAPTALDH1A1KMT2A | |
| SCHEMBL12701406 | 0.80 | MAPT (0.38) | MAPTALDH1A1KMT2A | |
| SCHEMBL23727421 | 0.78 | ALDH1A1 (0.40) | MAPTALDH1A1POLBKMT2A | |
| SCHEMBL21171596 | 0.78 | HRH3 (0.37) | — | |
| SCHEMBL19889936 | 0.78 | HRH3 (0.37) | — | |
| SCHEMBL12633308 | 0.78 | MAPT (0.41) | MAPTALDH1A1HTT | |
| SCHEMBL12633311 | 0.78 | MAPT (0.41) | MAPTALDH1A1HTT | |
| SCHEMBL12898753 | 0.77 | MAPT (0.56) | MAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3636643-A1 | NUCLEAR RECEPTOR MODULATORS (ROR) FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES | AbbVie Inc. (US) | 2020-04-15 | — | — | EP | disclosed |