Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 17/20 | 0.50 |
| ▸ | HRH1 | P35367 | 10/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
| ▸ | HTR7 | P34969 | 3/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1E | P28566 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | HTR5A | P47898 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3024067 | 0.90 | HRH1 (0.56) | HTR6HRH1ADRA2ADRD2HTR2A | |
| SCHEMBL3024070 | 0.90 | HRH1 (0.56) | HTR6HRH1ADRA2ADRD2HTR2A | |
| SCHEMBL3023789 | 0.84 | HTR6 (0.45) | HTR6HRH1ADRA2ADRD2HTR2A | |
| SCHEMBL3023786 | 0.84 | HTR6 (0.45) | HTR6HRH1ADRA2ADRD2HTR2A | |
| SCHEMBL3030251 | 0.82 | HTR6 (0.73) | HTR6HRH1ADRA2ADRD2HTR2A | |
| SCHEMBL3030253 | 0.82 | HTR6 (0.73) | HTR6HRH1ADRA2ADRD2HTR2A | |
| SCHEMBL3028589 | 0.80 | HTR6 (0.47) | HTR6HRH1ADRA2ADRD2HTR2A | |
| SCHEMBL3028591 | 0.80 | HTR6 (0.47) | HTR6HRH1ADRA2ADRD2HTR2A | |
| SCHEMBL12881878 | 0.78 | HRH1 (0.70) | HTR6HRH1ADRA2ADRD2HTR2A | |
| SCHEMBL3037847 | 0.76 | HTR6 (0.51) | HTR6HRH1ADRA2ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346332-A1 | PYRIDO (4,3-B) INDOLES CONTAINING RIGID MOIETIES | Medivation Technologies, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010051501-A1 | PYRIDO (4,3-B) INDOLES CONTAINING RIGID MOIETIES | MEDIVATION TECHNOLOGIES, INC. (US) | 2010-05-06 | — | — | WO | disclosed |