Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.45 |
| ▸ | MLYCD | O95822 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17554123 | 0.80 | NPC1 (0.68) | NPC1RAB9AHPGDALDH1A1MAPT | |
| SCHEMBL21870109 | 0.78 | NPC1 (0.51) | NPC1RAB9AHPGDALDH1A1MAPT | |
| SCHEMBL30560609 | 0.72 | RAB9A (0.81) | NPC1RAB9AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL5750828 | 0.72 | RAB9A (0.81) | NPC1RAB9AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL2352332 | 0.72 | RAB9A (1.00) | NPC1RAB9AALDH1A1MAPTHTT | |
| SCHEMBL4562581 | 0.69 | NPC1 (0.56) | NPC1RAB9AHPGDALDH1A1MAPT | |
| SCHEMBL8636926 | 0.69 | NPC1 (0.70) | NPC1RAB9AHPGDALDH1A1MAPT | |
| SCHEMBL21870107 | 0.69 | RAB9A (0.67) | NPC1RAB9AHPGDALDH1A1MAPT | |
| SCHEMBL17554087 | 0.68 | PPARG (0.76) | NPC1RAB9AHPGDALDH1A1MAPT | |
| SCHEMBL5856836 | 0.68 | HPGD (0.56) | NPC1RAB9AHPGDALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3628374-A2 | BCL-3 INHIBITORS | University College Cardiff Consultants Limited (GB) | 2020-04-01 | — | — | EP | disclosed |