Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 19/20 | 0.44 |
| ▸ | JAK2 | O60674 | 15/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21870794 | 0.85 | JAK1 (0.61) | JAK1JAK2TYK2 | |
| SCHEMBL21870763 | 0.81 | JAK2 (0.45) | JAK1JAK2 | |
| SCHEMBL23678674 | 0.77 | JAK2 (0.51) | JAK1JAK2 | |
| SCHEMBL23678811 | 0.77 | AURKA (0.42) | JAK2TYK2 | |
| SCHEMBL21870698 | 0.77 | JAK2 (0.61) | JAK1JAK2 | |
| SCHEMBL21870699 | 0.77 | JAK2 (0.44) | JAK1JAK2 | |
| SCHEMBL23678568 | 0.75 | JAK1 (0.70) | JAK1JAK2TYK2 | |
| SCHEMBL21870805 | 0.74 | JAK2 (0.52) | JAK1JAK2 | |
| SCHEMBL23678608 | 0.72 | JAK2 (0.48) | JAK1JAK2 | |
| SCHEMBL25959622 | 0.71 | JAK1 (0.81) | JAK1JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3854793-A1 | AROMATIC HETEROCYCLIC COMPOUND WITH KINASE INHIBITORY ACTIVITY | Shanghai Ennovabio Pharmaceuticals Co., Ltd. (CN) | 2021-07-28 | — | — | EP | disclosed |
| WO-2020057669-A1 | AROMATIC HETEROCYCLIC COMPOUND WITH KINASE INHIBITORY ACTIVITY | 上海轶诺药业有限公司 | 2020-03-26 | — | — | WO | disclosed |