Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2192226 | 0.94 | KMT2A (0.55) | KMT2AMEN1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL2186146 | 0.90 | CHRM4 (0.51) | KMT2AMEN1NPSR1POLBSMN1; SMN2 | |
| SCHEMBL2187555 | 0.90 | MEN1 (0.50) | KMT2AMEN1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL2186625 | 0.88 | MAPT (0.56) | KMT2AMEN1NPSR1POLBLMNA | |
| SCHEMBL27679665 | 0.86 | LMNA (0.46) | KMT2AMEN1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL2187717 | 0.86 | LMNA (0.53) | KMT2AMEN1NPSR1POLBSMN1; SMN2 | |
| SCHEMBL2188261 | 0.86 | LMNA (0.56) | KMT2AMEN1NPSR1POLBSMN1; SMN2 | |
| SCHEMBL27679669 | 0.85 | KMT2A (0.43) | KMT2AMEN1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL2186962 | 0.85 | LMNA (0.56) | KMT2AMEN1NPSR1POLBSMN1; SMN2 | |
| SCHEMBL2188273 | 0.85 | CHRM4 (0.52) | KMT2AMEN1NPSR1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |
| EP-1637529-A1 | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof | 4SC AG (DE) | 2006-03-22 | — | — | EP | disclosed |