Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 1/20 | 0.54 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.54 |
| ▸ | MTOR | P42345 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 10/20 | 0.50 |
| ▸ | RAB9A | P51151 | 10/20 | 0.50 |
| ▸ | PKM | P14618 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.47 |
| ▸ | SCD | O00767 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2187048 | 0.91 | NPC1 (0.63) | CSNK1DCSNK1EMTORNPC1RAB9A | |
| SCHEMBL2186689 | 0.89 | NPC1 (0.52) | MTORNPC1RAB9APKMSMN1; SMN2 | |
| SCHEMBL2186596 | 0.89 | CSNK1E (0.47) | CSNK1DCSNK1EMTORNPC1RAB9A | |
| SCHEMBL2189020 | 0.89 | CSNK1E (0.59) | CSNK1DCSNK1EMTORNPC1RAB9A | |
| SCHEMBL2186995 | 0.86 | IRAK4 (0.51) | CSNK1EMTORNPC1RAB9APKM | |
| SCHEMBL2186970 | 0.83 | NPC1 (0.49) | CSNK1DCSNK1EMTORNPC1RAB9A | |
| SCHEMBL2189066 | 0.82 | CSNK1E (0.69) | CSNK1DCSNK1EMTORNPC1RAB9A | |
| SCHEMBL2187178 | 0.80 | CSNK1D (0.45) | CSNK1DCSNK1EMTORNPC1RAB9A | |
| SCHEMBL11732060 | 0.80 | NPC1 (0.76) | MTORNPC1RAB9APKMSMN1; SMN2 | |
| SCHEMBL2187181 | 0.79 | CSNK1E (0.56) | CSNK1DCSNK1EMTORNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |