Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 11/20 | 0.49 |
| ▸ | RAB9A | P51151 | 10/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | PKM | P14618 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | SCD | O00767 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186596 | 0.91 | CSNK1E (0.47) | IRAK4NPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL2187048 | 0.90 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL2187175 | 0.86 | CSNK1D (0.54) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL2186970 | 0.86 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL2186689 | 0.86 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL2189020 | 0.83 | CSNK1E (0.59) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL2186997 | 0.81 | IRAK4 (0.41) | IRAK4NPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL28376966 | 0.80 | NPC1 (0.74) | IRAK4NPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL2187302 | 0.79 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL2189066 | 0.78 | CSNK1E (0.69) | NPC1RAB9ASMN1; SMN2PKMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |