Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10748084 | 0.92 | KDM4E (0.44) | KDM4EALDH1A1TSHRUSP2SMN1; SMN2 | |
| SCHEMBL10748936 | 0.92 | KDM4E (0.44) | KDM4EALDH1A1TSHRUSP2SMN1; SMN2 | |
| SCHEMBL4424654 | 0.81 | KDM4E (0.39) | KDM4EALDH1A1TSHRUSP2SMN1; SMN2 | |
| SCHEMBL1467291 | 0.81 | KDM4E (0.45) | KDM4EALDH1A1TSHRUSP2SMN1; SMN2 | |
| SCHEMBL4417627 | 0.81 | KDM4E (0.39) | KDM4EALDH1A1TSHRUSP2SMN1; SMN2 | |
| SCHEMBL23298992 | 0.81 | SMN1; SMN2 (0.45) | KDM4EALDH1A1TSHRUSP2SMN1; SMN2 | |
| SCHEMBL3307823 | 0.81 | KDM4E (0.46) | KDM4EALDH1A1TSHRUSP2SMN1; SMN2 | |
| SCHEMBL16666824 | 0.81 | ALDH1A1 (0.39) | KDM4EALDH1A1TSHRUSP2SMN1; SMN2 | |
| SCHEMBL16666821 | 0.81 | ALDH1A1 (0.39) | KDM4EALDH1A1TSHRUSP2SMN1; SMN2 | |
| SCHEMBL17284617 | 0.81 | KDM4E (0.39) | KDM4EALDH1A1TSHRUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3808743-A1 | HIV REPLICATION INHIBITING PYRIMIDINES | Janssen Pharmaceutica NV (BE) | 2021-04-21 | — | — | EP | disclosed |
| EP-2298761-B1 | HIV INHIBITING PYRIMIDINES DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2020-03-25 | — | — | EP | disclosed |