Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 7/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28072371 | 0.89 | CHRM2 (0.36) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| SCHEMBL10620127 | 0.81 | DPP4 (0.36) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| SCHEMBL23671413 | 0.78 | ATM (0.38) | — | |
| SCHEMBL21872660 | 0.78 | ATM (0.38) | — | |
| SCHEMBL6653691 | 0.78 | CHRM2 (0.52) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| SCHEMBL10449210 | 0.78 | CHRM2 (0.52) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| SCHEMBL14141163 | 0.78 | CHRM2 (0.52) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| SCHEMBL11410395 | 0.76 | DPP4 (0.36) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| SCHEMBL12990820 | 0.74 | CHRM2 (0.48) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| SCHEMBL18250835 | 0.74 | CHRM2 (0.48) | CHRM2CHRM4CHRM1CHRM3CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020072695-A1 | 8-AMINOISOQUINOLINE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2020-04-09 | — | — | WO | disclosed |