Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 6/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | KIT | P10721 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | FLT3 | P36888 | 2/20 | 0.31 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21873021 | 0.86 | CYP2C9 (0.33) | CYP2C9CYP3A4CYP1A2KITKDR | |
| SCHEMBL21872993 | 0.85 | CYP2C9 (0.38) | CYP2C9CYP3A4CYP1A2KITKDR | |
| SCHEMBL21873027 | 0.82 | CYP3A4 (0.38) | CYP2C9CYP3A4KITKDRFLT3 | |
| SCHEMBL21873058 | 0.81 | CYP3A4 (0.38) | CYP2C9CYP3A4CYP1A2KITKDR | |
| SCHEMBL21872994 | 0.78 | CYP2C9 (0.36) | CYP2C9CYP3A4CYP1A2KITKDR | |
| SCHEMBL21906349 | 0.77 | CYP2C9 (0.33) | CYP2C9CYP3A4CYP1A2 | |
| SCHEMBL21873088 | 0.77 | PDPK1 (0.39) | — | |
| SCHEMBL21873033 | 0.76 | CYP3A4 (0.36) | CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL21873005 | 0.75 | CYP2C9 (0.39) | CYP2C9CYP3A4CYP1A2KITKDR | |
| SCHEMBL21872977 | 0.74 | CYP2C9 (0.38) | CYP2C9CYP3A4CYP1A2KITKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3643715-A1 | NITROGEN HETEROARYL DERIVATIVE HAVING CSF1R INHIBITORY ACTIVITY, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2020-04-29 | — | — | EP | disclosed |