Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 16/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21873058 | 0.93 | CYP3A4 (0.38) | CYP3A4CYP2C9KITKDRFLT3 | |
| SCHEMBL21873088 | 0.89 | PDPK1 (0.39) | — | |
| SCHEMBL21873021 | 0.86 | CYP2C9 (0.33) | CYP3A4CYP2C9KITKDRFLT3 | |
| SCHEMBL21873144 | 0.84 | KIT (0.43) | CYP3A4CYP2C9KITKDRFLT3 | |
| SCHEMBL21873033 | 0.84 | CYP3A4 (0.36) | CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21872994 | 0.83 | CYP2C9 (0.36) | CYP3A4CYP2C9KITKDRFLT3 | |
| SCHEMBL21873020 | 0.82 | PDPK1 (0.40) | — | |
| SCHEMBL21872974 | 0.82 | CYP2C9 (0.33) | CYP3A4CYP2C9KITKDRFLT3 | |
| SCHEMBL21873014 | 0.81 | AURKA (0.40) | CYP3A4CYP2C9KITKDRFLT3 | |
| SCHEMBL21872978 | 0.78 | CYP3A4 (0.42) | CYP3A4CYP2C9KITKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3643715-A1 | NITROGEN HETEROARYL DERIVATIVE HAVING CSF1R INHIBITORY ACTIVITY, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2020-04-29 | — | — | EP | disclosed |