Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.65 |
| ▸ | RAB9A | P51151 | 11/20 | 0.65 |
| ▸ | PKM | P14618 | 4/20 | 0.65 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.65 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.53 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2189066 | 0.89 | CSNK1E (0.69) | NPC1RAB9APKMHSP90AA1PAX8 | |
| SCHEMBL2187048 | 0.83 | NPC1 (0.63) | NPC1RAB9APKMKLF5CSNK1E | |
| SCHEMBL2185625 | 0.81 | NPC1 (0.44) | NPC1RAB9APKMHSP90AA1PAX8 | |
| SCHEMBL2186970 | 0.81 | NPC1 (0.49) | NPC1RAB9APKMPOLBTDP1 | |
| SCHEMBL2186689 | 0.81 | NPC1 (0.52) | NPC1RAB9APKMKLF5SMN1; SMN2 | |
| SCHEMBL2187310 | 0.81 | NPC1 (0.52) | NPC1RAB9APKMHSP90AA1PAX8 | |
| SCHEMBL2187181 | 0.80 | CSNK1E (0.56) | NPC1RAB9APKMHSP90AA1PAX8 | |
| SCHEMBL15550757 | 0.80 | NPC1 (1.00) | NPC1RAB9APKMHSP90AA1PAX8 | |
| SCHEMBL30601616 | 0.80 | NPC1 (1.00) | NPC1RAB9APKMHSP90AA1PAX8 | |
| SCHEMBL2189020 | 0.79 | CSNK1E (0.59) | NPC1RAB9APKMPOLBKLF5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |