Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | PKM | P14618 | 3/20 | 0.52 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.52 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.45 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2189072 | 0.89 | CSNK1E (0.58) | NPC1RAB9APKMPAX8HSP90AA1 | |
| SCHEMBL2187052 | 0.83 | NPC1 (0.50) | NPC1RAB9APKMCSNK1ECSNK1D | |
| SCHEMBL2185628 | 0.82 | SMN1; SMN2 (0.39) | NPC1RAB9AL3MBTL1FOXO1CSNK1E | |
| SCHEMBL2186693 | 0.81 | MMP2 (0.46) | NPC1RAB9APKMLMNAKLF5 | |
| SCHEMBL2186979 | 0.81 | MAPT (0.44) | NPC1RAB9APKMLMNACSNK1E | |
| SCHEMBL2187182 | 0.81 | CSNK1E (0.47) | NPC1RAB9ACSNK1ECSNK1DPOLB | |
| SCHEMBL2187302 | 0.81 | NPC1 (0.65) | NPC1RAB9APKMPAX8HSP90AA1 | |
| SCHEMBL2187178 | 0.80 | CSNK1D (0.45) | NPC1RAB9APKMCSNK1ECSNK1D | |
| SCHEMBL2189024 | 0.79 | CSNK1E (0.49) | NPC1PKMLMNAL3MBTL1CSNK1E | |
| SCHEMBL2186997 | 0.79 | IRAK4 (0.41) | NPC1RAB9APKMLMNACSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |