Sugi Predict

Sugi Predict / Compounds / SCHEMBL21873563

SCHEMBL21873563

SCHEMBL21873563

COc1ccc(C(OCC(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)OCCn2cnc3c(NC(=O)c4ccccc4)ncnc32)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ HDAC1 Q13547 1/20 0.39
▸ HDAC6 Q9UBN7 1/20 0.39
▸ ABL1 P00519 1/20 0.36
▸ NSD3 Q9BZ95 1/20 0.35
▸ KDR P35968 2/20 0.34
▸ FLT4 P35916 1/20 0.34
▸ RET P07949 1/20 0.33
▸ TMIGD3 P0DMS9 2/20 0.33
▸ ADORA3 P0DMS8 2/20 0.33
▸ SLC6A1 P30531 2/20 0.33
▸ ADORA1 P30542 1/20 0.33
▸ SLC6A11 P48066 1/20 0.33
▸ EGFR P00533 1/20 0.33
▸ ERBB3 P21860 1/20 0.33
▸ CDK5 Q00535 1/20 0.33
▸ CDK5R1 Q15078 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21873560 1.00 HDAC1 (0.39) HDAC1HDAC6ABL1NSD3KDR
SCHEMBL21873559 0.89 HDAC1 (0.42) HDAC1HDAC6ABL1NSD3KDR
SCHEMBL21873561 0.89 HDAC1 (0.42) HDAC1HDAC6ABL1NSD3KDR
SCHEMBL30688740 0.87 FLT4 (0.37) HDAC1HDAC6ABL1KDRFLT4
SCHEMBL21873584 0.87 FLT4 (0.37) HDAC1HDAC6ABL1KDRFLT4
SCHEMBL21873587 0.87 FLT4 (0.37) HDAC1HDAC6ABL1KDRFLT4
SCHEMBL31543020 0.86 CCNB2 (0.38) HDAC1HDAC6KDRFLT4RET
SCHEMBL29259405 0.86 CCNB2 (0.38) HDAC1HDAC6KDRFLT4RET
SCHEMBL5179291 0.80 HDAC1 (0.40) HDAC1HDAC6ABL1KDRFLT4
SCHEMBL16198031 0.78 HDAC1 (0.47) HDAC1HDAC6ABL1KDRFLT4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110678447-B Modified nucleic acid monomer compounds and oligonucleotide analogues 卫材R&D管理有限公司 2023-12-12 — — CN disclosed
US-11208429-B2 Modified nucleic acid monomer compound and oligonucleic acid analog EISAI R&D MANAGEMENT CO., LTD. (JP) 2021-12-28 — — US disclosed
EP-3643706-A9 MODIFIED NUCLEIC ACID MONOMER COMPOUND AND OLIGONUCLEIC ACID ANALOG Eisai R&D Management Co., Ltd. (JP) 2020-09-23 — — EP disclosed
US-20200216488-A1 MODIFIED NUCLEIC ACID MONOMER COMPOUND AND OLIGONUCLEIC ACID ANALOG EISAI R&D MANAGEMENT CO., LTD. (JP) 2020-07-09 — — US disclosed
EP-3643706-A1 MODIFIED NUCLEIC ACID MONOMER COMPOUND AND OLIGONUCLEIC ACID ANALOG Eisai R&D Management Co., Ltd. (JP) 2020-04-29 — — EP disclosed
CN-110678447-A Modified nucleic acid monomer compounds and oligonucleotide analogs 卫材R&D管理有限公司 2020-01-10 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200216488-A1 MODIFIED NUCLEIC ACID MONOMER COMPOUND AND OLIGONUCLEIC ACID ANALOG POLRMT, DERA, PCNA HDAC1 1164/4885HDAC6 3233/4885ABL1 4291/4885
US-11208429-B2 Modified nucleic acid monomer compound and oligonucleic acid analog POLRMT, DERA, PCNA HDAC1 1164/4885HDAC6 3233/4885ABL1 4291/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.