Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 20/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8160841 | 0.80 | GRM2 (0.40) | GRM2 | |
| SCHEMBL1038947 | 0.79 | GRM2 (0.53) | GRM2 | |
| SCHEMBL1828629 | 0.76 | GRM2 (0.57) | GRM2 | |
| SCHEMBL1038095 | 0.76 | GRM2 (0.54) | GRM2 | |
| SCHEMBL14829162 | 0.71 | GRM2 (0.43) | GRM2 | |
| SCHEMBL1039006 | 0.70 | ALDH1A1 (0.55) | GRM2 | |
| SCHEMBL1078962 | 0.70 | KDM4C (0.45) | GRM2 | |
| SCHEMBL2634726 | 0.69 | GRM2 (0.70) | GRM2 | |
| SCHEMBL1039083 | 0.69 | GRM2 (1.00) | GRM2 | |
| SCHEMBL12030208 | 0.69 | GRM2 (0.70) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252937-B2 | 1,3-disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones | Janssen Pharmaceuticals, Inc. (US) | 2012-08-28 | — | — | US | disclosed |
| CN-101848893-B | 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones | ADDEX PHARMACEUTICALS SA | 2012-06-06 | — | — | CN | disclosed |
| EP-2200985-B1 | 1,3-DISUBSTITUTED 4-(ARYL-X-PHENYL)-1H-PYRIDIN-2-ONES | ORTHO MCNEIL JANSSEN PHARM (US) | 2011-07-13 | — | — | EP | disclosed |
| US-20100286206-A1 | 1,3-DISUBSTITUTED 4-(ARYL-X-PHENYL)-1H-PYRIDIN-2-ONES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | US | disclosed |
| CN-101848893-A | 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones | ADDEX PHARMACEUTICALS SA | 2010-09-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286206-A1 | 1,3-DISUBSTITUTED 4-(ARYL-X-PHENYL)-1H-PYRIDIN-2-ONES | GRM2, GRM1, GRM3 | GRM2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.