Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 16/20 | 0.68 |
| ▸ | HRH1 | P35367 | 2/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.68 |
| ▸ | DRD2 | P14416 | 1/20 | 0.68 |
| ▸ | HTR2A | P28223 | 1/20 | 0.68 |
| ▸ | HTR2C | P28335 | 1/20 | 0.68 |
| ▸ | HTR7 | P34969 | 1/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CD4 | P01730 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3037847 | 0.87 | HTR6 (0.51) | HTR6HRH1ADRA2ADRD2HTR2A | |
| SCHEMBL3037849 | 0.87 | HTR6 (0.51) | HTR6HRH1ADRA2ADRD2HTR2A | |
| SCHEMBL3018778 | 0.81 | HTR6 (1.00) | HTR6HRH1ADRA2ADRD2HTR2A | |
| SCHEMBL3036979 | 0.81 | HTR6 (1.00) | HTR6HRH1ADRA2ADRD2HTR2A | |
| SCHEMBL3018781 | 0.81 | HTR6 (1.00) | HTR6HRH1ADRA2ADRD2HTR2A | |
| SCHEMBL3024366 | 0.80 | HTR6 (0.73) | HTR6HRH1ADRA2ADRD2HTR2A | |
| SCHEMBL3024370 | 0.80 | HTR6 (0.73) | HTR6HRH1ADRA2ADRD2HTR2A | |
| SCHEMBL3040158 | 0.79 | HTR6 (0.52) | HTR6HRH1ADRA2ADRD2HTR2A | |
| SCHEMBL3040162 | 0.79 | HTR6 (0.52) | HTR6HRH1ADRA2ADRD2HTR2A | |
| SCHEMBL3243224 | 0.78 | HTR6 (0.85) | HTR6HRH1ADRA2ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346332-A1 | PYRIDO (4,3-B) INDOLES CONTAINING RIGID MOIETIES | Medivation Technologies, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010051501-A1 | PYRIDO (4,3-B) INDOLES CONTAINING RIGID MOIETIES | MEDIVATION TECHNOLOGIES, INC. (US) | 2010-05-06 | — | — | WO | disclosed |