Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GPR6 | P46095 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL21819605 | 0.90 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1LMNAPKMMEN1 | |
| SCHEMBL21882029 | 0.85 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1LMNAPKMCHRM3 | |
| SCHEMBL1721295 | 0.83 | CYP2D6 (0.67) | SMN1; SMN2MEN1KMT2AHTTCYP2D6 | |
| SCHEMBL27606796 | 0.83 | HTT (0.47) | SMN1; SMN2ALDH1A1KMT2AHTTCYP2D6 | |
| SCHEMBL717372 | 0.83 | HTT (0.69) | SMN1; SMN2ALDH1A1HTTCYP2D6SIGMAR1 | |
| Bromide SCHEMBL7777483 | 0.82 | CYP2D6 (0.65) | SMN1; SMN2MEN1KMT2AHTTCYP2D6 | |
| Hydrochloric Acid SCHEMBL6578952 | 0.81 | GAA (0.47) | SMN1; SMN2PKMHTTCYP2D6 | |
| SCHEMBL941910 | 0.80 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1LMNAPKMMEN1 | |
| SCHEMBL28789371 | 0.80 | PLK1 (0.51) | SMN1; SMN2ALDH1A1PKMHTTCYP2D6 | |
| SCHEMBL21882372 | 0.78 | CNR1 (0.48) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11166942-B2 | Inhibitors of integrated stress response pathway | Praxis Biotech LLC (US) | 2021-11-09 | — | — | US | disclosed |
| US-20200101047-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC | 2020-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11166942-B2 | Inhibitors of integrated stress response pathway | ATF4, DDIT3, ATF1 | SMN1; SMN2 3465/4885ALDH1A1 4073/4885LMNA 4459/4885 |
| US-20200101047-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | SMN1; SMN2 3465/4885ALDH1A1 4073/4885LMNA 4459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.