Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 13/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 11/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21882350 | 0.87 | CSF1R (0.33) | CSF1RPDGFRBPDGFRAFLT3MET | |
| SCHEMBL21882303 | 0.86 | CSF1R (0.34) | CSF1RPDGFRBPDGFRAKITFLT3 | |
| SCHEMBL21426351 | 0.82 | CSF1R (0.56) | CSF1RPDGFRBPDGFRAKITFLT3 | |
| SCHEMBL21882296 | 0.81 | CSF1R (0.34) | CSF1RPDGFRBPDGFRAKITFLT3 | |
| SCHEMBL21882345 | 0.79 | TGFBR1 (0.36) | CSF1RPDGFRBPDGFRAKITTGFBR1 | |
| SCHEMBL21882305 | 0.79 | RAF1 (0.38) | CSF1RPDGFRBPDGFRALMNAMET | |
| SCHEMBL21425572 | 0.76 | CSF1R (0.35) | CSF1RPDGFRBPDGFRAFLT3TGFBR1 | |
| SCHEMBL21772037 | 0.74 | KDR (0.51) | CSF1RPDGFRBPDGFRAFLT3KDR | |
| SCHEMBL21882307 | 0.72 | CSF1R (0.32) | CSF1RPDGFRBPDGFRATGFBR1 | |
| SCHEMBL27118054 | 0.71 | CSF1R (0.46) | CSF1RPDGFRBPDGFRAKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3632907-A1 | N-(AZAARYL)CYCLOLACTAM-1-CARBOXAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2020-04-08 | — | — | EP | disclosed |