Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 16/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 7/20 | 0.38 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2189056 | 0.91 | PTGDR2 (0.41) | PTGDR2TBXA2RPTGDRPSIP1 | |
| SCHEMBL2187156 | 0.85 | PTGDR2 (0.39) | PTGDR2TBXA2RPTGDRPSIP1 | |
| SCHEMBL2188128 | 0.85 | KMT2A (0.41) | PTGDR2TBXA2R | |
| SCHEMBL2190008 | 0.84 | PTGDR2 (0.42) | PTGDR2TBXA2RPTGDR | |
| SCHEMBL2187304 | 0.84 | PTGDR2 (0.40) | PTGDR2TBXA2RPTGDRPSIP1 | |
| SCHEMBL2188973 | 0.78 | PSIP1 (0.38) | PTGDR2TBXA2RPTGDRPSIP1 | |
| SCHEMBL3663654 | 0.77 | PTGDR2 (0.65) | PTGDR2TBXA2RPTGDR | |
| SCHEMBL15428826 | 0.77 | PTGDR2 (0.65) | PTGDR2TBXA2RPTGDR | |
| SCHEMBL2190622 | 0.76 | PTGDR2 (0.48) | PTGDR2PTGDR | |
| SCHEMBL12002810 | 0.76 | DRD4 (0.41) | PTGDR2PTGDRPSIP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346865-A1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | Merck Frosst Canada Ltd. (CA) | 2011-07-27 | — | — | EP | disclosed |
| US-20110172263-A1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA LTD (CA) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172263-A1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | PTGER2, PTGDR2, PTGDR | PTGDR2 2/4885TBXA2R 28/4885PTGDR 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.