Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 11/20 | 0.81 |
| ▸ | USP2 | O75604 | 3/20 | 0.81 |
| ▸ | LMNA | P02545 | 3/20 | 0.81 |
| ▸ | MEN1 | O00255 | 1/20 | 0.81 |
| ▸ | TP53 | P04637 | 1/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.81 |
| ▸ | RORC | P51449 | 3/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.55 |
| ▸ | OSBP | P22059 | 1/20 | 0.55 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.55 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | POLA1 | P09884 | 1/20 | 0.53 |
| ▸ | TOP2A | P11388 | 1/20 | 0.53 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | CDC25A | P30304 | 1/20 | 0.52 |
| ▸ | CDC25B | P30305 | 1/20 | 0.52 |
| ▸ | INPP5D | Q92835 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cholestan-3Beta,5Alpha,6Beta-Triol SCHEMBL18504407 | 0.90 | NPC1L1 (1.00) | NPC1L1USP2LMNAMEN1TP53 | |
| Cholestan-3Beta,5Alpha,6Beta-Triol SCHEMBL15935528 | 0.90 | NPC1L1 (1.00) | NPC1L1USP2LMNAMEN1TP53 | |
| Cholestan-3Beta,5Alpha,6Beta-Triol SCHEMBL14490136 | 0.90 | NPC1L1 (1.00) | NPC1L1USP2LMNAMEN1TP53 | |
| Cholestan-3Beta,5Alpha,6Beta-Triol SCHEMBL25277367 | 0.90 | NPC1L1 (1.00) | NPC1L1USP2LMNAMEN1TP53 | |
| Cholestan-3Beta,5Alpha,6Beta-Triol SCHEMBL3421500 | 0.90 | NPC1L1 (1.00) | NPC1L1USP2LMNAMEN1TP53 | |
| Cholestan-3Beta,5Alpha,6Beta-Triol SCHEMBL23647982 | 0.90 | NPC1L1 (1.00) | NPC1L1USP2LMNAMEN1TP53 | |
| Cholestan-3Beta,5Alpha,6Beta-Triol SCHEMBL14360501 | 0.90 | NPC1L1 (1.00) | NPC1L1USP2LMNAMEN1TP53 | |
| Cholestan-3Beta,5Alpha,6Beta-Triol SCHEMBL21000300 | 0.90 | NPC1L1 (1.00) | NPC1L1USP2LMNAMEN1TP53 | |
| Cholestan-3Beta,5Alpha,6Beta-Triol SCHEMBL17049790 | 0.90 | NPC1L1 (1.00) | NPC1L1USP2LMNAMEN1TP53 | |
| Cholestan-3Beta,5Alpha,6Beta-Triol SCHEMBL29153013 | 0.90 | NPC1L1 (1.00) | NPC1L1USP2LMNAMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020069267-A1 | HALOGENATED CHOLESTEROL ANALOGUES AND METHODS OF MAKING AND USING SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-04-02 | — | — | WO | disclosed |