Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15143918 | 0.90 | SMN1; SMN2 (0.79) | SMN1; SMN2NPC1RAB9AHPGDCYP1A2 | |
| SCHEMBL10192163 | 0.83 | NPC1 (0.69) | SMN1; SMN2NPC1RAB9AHPGDCYP1A2 | |
| SCHEMBL13797608 | 0.81 | RAB9A (0.67) | SMN1; SMN2NPC1RAB9AHPGDCYP1A2 | |
| SCHEMBL12996859 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2NPC1RAB9AHPGDCYP1A2 | |
| SCHEMBL17904708 | 0.81 | NPC1 (0.67) | SMN1; SMN2NPC1RAB9AHPGDCYP1A2 | |
| SCHEMBL9335595 | 0.81 | HPGD (0.67) | SMN1; SMN2NPC1RAB9AHPGDCYP1A2 | |
| SCHEMBL13513998 | 0.81 | RAB9A (0.67) | SMN1; SMN2NPC1RAB9AHPGDCYP1A2 | |
| SCHEMBL18814224 | 0.81 | HPGD (0.67) | SMN1; SMN2NPC1RAB9AHPGDCYP1A2 | |
| Propham SCHEMBL67344 | 0.81 | SMN1; SMN2 (0.66) | SMN1; SMN2NPC1RAB9AHPGDCYP1A2 | |
| Propham SCHEMBL8536412 | 0.81 | SMN1; SMN2 (0.66) | SMN1; SMN2NPC1RAB9AHPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697327-B1 | INSECTICIDAL SPIROINDANE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-07-13 | — | — | EP | disclosed |