Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 4/20 | 0.40 |
| ▸ | MET | P08581 | 3/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | FER | P16591 | 2/20 | 0.40 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.40 |
| ▸ | MERTK | Q12866 | 2/20 | 0.40 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | STK10 | O94804 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30365234 | 1.00 | KDR (0.52) | KDRPDGFRBFLT3METRET | |
| SCHEMBL21884880 | 1.00 | KDR (0.52) | KDRPDGFRBFLT3METRET | |
| SCHEMBL21886116 | 1.00 | KDR (0.52) | KDRPDGFRBFLT3METRET | |
| SCHEMBL21884882 | 0.93 | KDR (0.57) | KDRPDGFRBFLT3METRET | |
| SCHEMBL21884881 | 0.93 | KDR (0.57) | KDRPDGFRBFLT3METRET | |
| SCHEMBL30364944 | 0.91 | KDR (0.54) | KDRPDGFRBFLT3METRET | |
| SCHEMBL21884885 | 0.91 | KDR (0.54) | KDRPDGFRBFLT3METRET | |
| SCHEMBL21884833 | 0.90 | KDR (0.56) | KDRPDGFRBFLT3METRET | |
| SCHEMBL21884864 | 0.88 | KDR (0.53) | KDRPDGFRBFLT3METRET | |
| SCHEMBL21885577 | 0.88 | KDR (0.52) | KDRPDGFRBFLT3METRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020057403-A1 | INDOLE DERIVATIVE AND MEDICAL APPLICATION THEREOF | 北京越之康泰生物医药科技有限公司 | 2020-03-26 | — | — | WO | disclosed |