Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 3/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GLS | O94925 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.39 |
| ▸ | F9 | P00740 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | G6PD | P11413 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21884446 | 0.88 | KAT6A (0.43) | KAT6ALMNAGLSERCC1ERCC4 | |
| SCHEMBL18397864 | 0.83 | TP53 (0.45) | KAT6APIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL18397923 | 0.74 | PRKDC (0.48) | KAT6APIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1316515 | 0.71 | ACLY (0.49) | KAT6ATBK1 | |
| SCHEMBL18397880 | 0.71 | RXFP1 (0.43) | KAT6APIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6774142 | 0.70 | MAPT (0.51) | KAT6APIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7632450 | 0.70 | MAPT (0.50) | PIK3CDPIK3CAPIK3CBPIK3CGLMNA | |
| SCHEMBL16983933 | 0.70 | MAPT (0.46) | LMNATP53ERCC1ERCC4LRRK2 | |
| SCHEMBL29564059 | 0.69 | KDM4E (0.45) | KAT6ALMNAERCC1ERCC4LRRK2 | |
| SCHEMBL18397856 | 0.69 | PTPN1 (0.46) | KAT6APIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020061473-A1 | SMALL MOLECULES TARGETING MUTANT MAMMALIAN PROTEINS | JNANA THERAPEUTICS, INC. (US) | 2020-03-26 | — | — | WO | disclosed |