Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.31 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.31 |
| ▸ | TERT | O14746 | 1/20 | 0.31 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21801074 | 0.87 | TDP1 (0.38) | ADORA3TDP1L3MBTL1TERTKCNA3 | |
| SCHEMBL30629637 | 0.87 | TDP1 (0.38) | ADORA3TDP1L3MBTL1TERTKCNA3 | |
| SCHEMBL21801122 | 0.84 | TDP1 (0.37) | ADORA3TDP1L3MBTL1 | |
| SCHEMBL21866050 | 0.79 | TDP1 (0.34) | TDP1L3MBTL1MAOBABCG2ABCC1 | |
| SCHEMBL21801132 | 0.79 | CSNK2A2 (0.41) | TDP1L3MBTL1ABCG2ABCB1 | |
| SCHEMBL21801129 | 0.79 | CSNK2A2 (0.41) | TDP1L3MBTL1ABCG2ABCB1 | |
| SCHEMBL21801082 | 0.78 | TDP1 (0.36) | TDP1L3MBTL1KCNA3 | |
| SCHEMBL30629627 | 0.78 | TDP1 (0.36) | TDP1L3MBTL1KCNA3 | |
| SCHEMBL21886767 | 0.78 | CSNK2A2 (0.41) | MAOBABCG2 | |
| SCHEMBL21865634 | 0.77 | ABCB1 (0.43) | MAOBABCG2ABCC1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3849966-B1 | FLAVONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | HOFFMANN LA ROCHE (CH) | 2023-10-25 | — | — | EP | disclosed |
| WO-2020052774-A1 | FLAVONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2020-03-19 | — | — | WO | disclosed |