Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 3/20 | 0.35 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.33 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.32 |
| ▸ | ACSL3 | O95573 | 1/20 | 0.31 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.31 |
| ▸ | ACSL6 | Q9UKU0 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.31 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.31 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.31 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.31 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21801082 | 1.00 | TDP1 (0.36) | TDP1L3MBTL1TTRERAP1CYSLTR1 | |
| SCHEMBL30629637 | 0.91 | TDP1 (0.38) | TDP1L3MBTL1TTRCYSLTR1HPGD | |
| SCHEMBL21801074 | 0.91 | TDP1 (0.38) | TDP1L3MBTL1TTRCYSLTR1HPGD | |
| SCHEMBL21801132 | 0.90 | CSNK2A2 (0.41) | TDP1L3MBTL1TTRCYSLTR1HPGD | |
| SCHEMBL21801129 | 0.90 | CSNK2A2 (0.41) | TDP1L3MBTL1TTRCYSLTR1HPGD | |
| SCHEMBL30744119 | 0.90 | TDP1 (0.36) | TDP1L3MBTL1HPGDALDH1A1KDM4E | |
| SCHEMBL21801066 | 0.90 | TDP1 (0.36) | TDP1L3MBTL1HPGDALDH1A1KDM4E | |
| SCHEMBL21866050 | 0.89 | TDP1 (0.34) | TDP1L3MBTL1ERAP1CYSLTR1KCNA3 | |
| SCHEMBL21801199 | 0.88 | ABCG2 (0.43) | TDP1L3MBTL1CYSLTR1HPGDALDH1A1 | |
| SCHEMBL21801198 | 0.88 | ABCG2 (0.43) | TDP1L3MBTL1CYSLTR1HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112601743-B | Flavone compounds for the treatment and prevention of hepatitis b virus diseases | 豪夫迈·罗氏有限公司 | 2023-12-19 | — | — | CN | claimed |
| CN-112601743-B | Flavone compounds for the treatment and prevention of hepatitis b virus diseases | 豪夫迈·罗氏有限公司 | 2023-12-19 | — | — | CN | disclosed |
| EP-3849966-B1 | FLAVONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | HOFFMANN LA ROCHE (CH) | 2023-10-25 | — | — | EP | disclosed |