Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 4/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL416174 | 0.81 | JAK2 (0.60) | THRBJAK2KDM4CCYP1A2KDM4E | |
| SCHEMBL9943788 | 0.80 | JAK2 (0.55) | THRBJAK2CYP1A2GAAKDM4E | |
| SCHEMBL12364192 | 0.78 | L3MBTL1 (0.46) | THRBJAK2KDM4CCYP1A2GAA | |
| SCHEMBL17930149 | 0.78 | JAK2 (0.67) | THRBJAK2CYP1A2GAAALDH1A1 | |
| SCHEMBL24761226 | 0.77 | CYP1A2 (0.42) | THRBJAK2KDM4CCYP1A2GAA | |
| SCHEMBL1917991 | 0.77 | CYP1A2 (0.42) | THRBJAK2KDM4CCYP1A2GAA | |
| SCHEMBL1224786 | 0.77 | TYMP (0.45) | THRBJAK2KDM4CCYP1A2GAA | |
| SCHEMBL13272912 | 0.77 | CYP1A2 (0.42) | THRBJAK2KDM4CCYP1A2GAA | |
| SCHEMBL31330663 | 0.77 | KDM4C (0.51) | THRBJAK2KDM4CCYP1A2GAA | |
| SCHEMBL1270655 | 0.77 | CYP1A2 (0.39) | THRBJAK2KDM4CCYP1A2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12054488-B2 | Pyrazolopyrimidine compound and preparation method therefor and use thereof in preparation of anti-cancer drug | SUZHOU RAYMON PHARMACEUTICALS COMPANY, LTD. (CN) | 2024-08-06 | — | — | US | disclosed |
| CN-110950868-B | Pyrazolopyrimidine compound, preparation method thereof and application of pyrazolopyrimidine compound in preparation of anti-cancer drugs | 苏州锐明新药研发有限公司 | 2022-05-13 | — | — | CN | disclosed |
| US-20220106316-A2 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | SUZHOU RAYMON PHARMACEUTICALS COMPANY, LTD. (CN) | 2022-04-07 | — | — | US | disclosed |
| US-20210340146-A1 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | SUZHOU RAYMON PHARMACEUTICALS COMPANY LTD (CN) | 2021-11-04 | — | — | US | disclosed |
| US-20210340146-A1 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | SUZHOU RAYMON PHARMACEUTICALS COMPANY LTD (CN) | 2021-11-04 | — | — | US | disclosed |
| CN-110950868-A | Pyrazolopyrimidine compound, preparation method thereof and application thereof in preparing anti-cancer drugs | 苏州锐明新药研发有限公司 | 2020-04-03 | — | — | CN | disclosed |
| WO-2020063636-A1 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | 苏州锐明新药研发有限公司 | 2020-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220106316-A2 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | PIK3CA, PIK3CD, PIK3R5 | THRB 4069/4885JAK2 53/4885KDM4C 3453/4885 |
| US-20210340146-A1 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | PIK3CA, PIK3CD, PIK3R5 | THRB 4069/4885JAK2 53/4885KDM4C 3453/4885 |
| US-12054488-B2 | Pyrazolopyrimidine compound and preparation method therefor and use thereof in preparation of anti-cancer drug | PIK3CA, PIK3CD, PIK3R5 | THRB 4069/4885JAK2 53/4885KDM4C 3453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.