Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29502585 | 0.82 | NPSR1 (0.54) | NPSR1KDM4CALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL117827 | 0.82 | NPSR1 (0.54) | NPSR1KDM4CALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL9943790 | 0.81 | NPC1 (0.44) | NPSR1ALDH1A1KDM4ERAB9AL3MBTL1 | |
| SCHEMBL12338897 | 0.79 | NPSR1 (0.50) | NPSR1KDM4CALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL1554821 | 0.79 | HCAR2 (0.31) | — | |
| SCHEMBL31484056 | 0.78 | NPSR1 (0.48) | NPSR1KDM4CALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL29352298 | 0.78 | NPSR1 (0.48) | NPSR1KDM4CALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL719555 | 0.78 | NPSR1 (0.48) | NPSR1KDM4CALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL109063 | 0.78 | NPSR1 (0.48) | NPSR1ALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL30668014 | 0.78 | NPSR1 (0.48) | NPSR1ALDH1A1KDM4ESMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12054488-B2 | Pyrazolopyrimidine compound and preparation method therefor and use thereof in preparation of anti-cancer drug | SUZHOU RAYMON PHARMACEUTICALS COMPANY, LTD. (CN) | 2024-08-06 | — | — | US | disclosed |
| US-20220106316-A2 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | SUZHOU RAYMON PHARMACEUTICALS COMPANY, LTD. (CN) | 2022-04-07 | — | — | US | disclosed |
| US-20210340146-A1 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | SUZHOU RAYMON PHARMACEUTICALS COMPANY LTD (CN) | 2021-11-04 | — | — | US | disclosed |
| US-20210340146-A1 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | SUZHOU RAYMON PHARMACEUTICALS COMPANY LTD (CN) | 2021-11-04 | — | — | US | disclosed |
| WO-2020063636-A1 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | 苏州锐明新药研发有限公司 | 2020-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220106316-A2 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | PIK3CA, PIK3CD, PIK3R5 | NPSR1 4429/4885KDM4C 3453/4885ALDH1A1 1096/4885 |
| US-20210340146-A1 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | PIK3CA, PIK3CD, PIK3R5 | NPSR1 4429/4885KDM4C 3453/4885ALDH1A1 1096/4885 |
| US-12054488-B2 | Pyrazolopyrimidine compound and preparation method therefor and use thereof in preparation of anti-cancer drug | PIK3CA, PIK3CD, PIK3R5 | NPSR1 4429/4885KDM4C 3453/4885ALDH1A1 1096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.