Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18615075 | 0.85 | ADORA2A (0.47) | JAK2MAPTHSD17B10TDP1KDM4E | |
| SCHEMBL18615183 | 0.83 | JAK2 (0.39) | JAK2MAPTPDPK1KDM4EALDH1A1 | |
| SCHEMBL2271103 | 0.81 | KDM4E (0.45) | JAK2MAPTESR1ESR2TDP1 | |
| SCHEMBL2144889 | 0.80 | PDPK1 (0.50) | JAK2MAPTHSD17B10PDPK1TP53 | |
| SCHEMBL18615118 | 0.75 | KDM4E (0.40) | JAK2MAPTPDPK1TP53ESR1 | |
| SCHEMBL5774585 | 0.73 | PDPK1 (0.44) | JAK2MAPTHSD17B10PDPK1TP53 | |
| SCHEMBL2144714 | 0.73 | JAK2 (0.60) | JAK2MAPTKDM4EALDH1A1GAA | |
| SCHEMBL18952612 | 0.70 | PSEN1 (0.45) | JAK2MAPTHSD17B10TP53KDM4E | |
| SCHEMBL2258043 | 0.70 | HPGD (0.41) | JAK2MAPTHSD17B10TP53KDM4E | |
| SCHEMBL21887506 | 0.69 | PSEN1 (0.43) | MAPTHSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10604517-B2 | Bridged piperidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2020-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10604517-B2 | Bridged piperidine derivatives | HPGDS, APP, PSEN1 | JAK2 2869/4885MAPT 240/4885HSD17B10 1024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.