Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 0.81 |
| ▸ | STAT3 | P40763 | 4/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30349436 | 0.89 | TYK2 (1.00) | TYK2STAT3 | |
| SCHEMBL21887776 | 0.89 | TYK2 (1.00) | TYK2STAT3 | |
| SCHEMBL21811163 | 0.89 | TYK2 (1.00) | TYK2STAT3 | |
| SCHEMBL21811269 | 0.89 | TYK2 (1.00) | TYK2STAT3 | |
| SCHEMBL30349300 | 0.87 | TYK2 (0.84) | TYK2STAT3 | |
| SCHEMBL21887515 | 0.87 | TYK2 (0.84) | TYK2STAT3 | |
| SCHEMBL21811186 | 0.87 | TYK2 (0.84) | TYK2STAT3 | |
| SCHEMBL21811321 | 0.87 | TYK2 (0.84) | TYK2STAT3 | |
| SCHEMBL24224248 | 0.86 | TYK2 (0.78) | TYK2STAT3 | |
| SCHEMBL22092669 | 0.86 | TYK2 (0.78) | TYK2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3849981-B1 | PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSORIASIS AND SYSTEMIC LUPUS ERYTHEMATOSUS | LILLY CO ELI (US) | 2023-02-01 | — | — | EP | disclosed |
| WO-2020055636-A1 | PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSORIASIS AND SYSTEMIC LUPUS ERYTHEMATOSUS | ELI LILLY AND COMPANY (US) | 2020-03-19 | — | — | WO | disclosed |