Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.39 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21811164 | 0.93 | AKR1C3 (0.46) | KCNH2MAPTHTTKDM4EALDH1A1 | |
| SCHEMBL21887781 | 0.93 | NPSR1 (0.43) | KCNH2MAPTHTTKDM4EALDH1A1 | |
| SCHEMBL21887372 | 0.88 | TDP1 (0.44) | MAPTHTTKDM4EALDH1A1NPSR1 | |
| SCHEMBL24961730 | 0.88 | MEN1 (0.43) | KCNH2MAPTALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL21887777 | 0.88 | MAPT (0.44) | MAPTHTTKDM4EALDH1A1NPSR1 | |
| SCHEMBL21887371 | 0.85 | TYK2 (0.62) | TYK2STAT3 | |
| SCHEMBL30162010 | 0.85 | TYK2 (0.62) | TYK2STAT3 | |
| SCHEMBL21887375 | 0.83 | KDM4E (0.42) | MAPTHTTKDM4EALDH1A1NPSR1 | |
| SCHEMBL22092692 | 0.82 | POLB (0.44) | MAPTHTTKDM4EALDH1A1NPSR1 | |
| SCHEMBL31245701 | 0.82 | TYK2 (0.64) | TYK2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11891400-B2 | Pyrazolo[1,5-a]pyrimidine-3-carboxamide derivatives useful in the treatment of psoriasis and systemic lupus erythematosus | ELI LILLY AND COMPANY (US) | 2024-02-06 | — | — | US | disclosed |
| EP-3849981-B1 | PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSORIASIS AND SYSTEMIC LUPUS ERYTHEMATOSUS | LILLY CO ELI (US) | 2023-02-01 | — | — | EP | disclosed |
| US-20210188861-A1 | PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSORIASIS AND SYSTEMIC LUPUS ERYTHEMATOSUS | ELI LILLY AND COMPANY | 2021-06-24 | — | — | US | disclosed |
| US-20210188861-A1 | PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSORIASIS AND SYSTEMIC LUPUS ERYTHEMATOSUS | ELI LILLY AND COMPANY | 2021-06-24 | — | — | US | disclosed |
| WO-2020055636-A1 | PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSORIASIS AND SYSTEMIC LUPUS ERYTHEMATOSUS | ELI LILLY AND COMPANY (US) | 2020-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11891400-B2 | Pyrazolo[1,5-a]pyrimidine-3-carboxamide derivatives useful in the treatment of psoriasis and systemic lupus erythematosus | SSB, TPMT, SPHK1 | KCNH2 1707/4885MAPT 4226/4885HTT 4861/4885 |
| US-20210188861-A1 | PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSORIASIS AND SYSTEMIC LUPUS ERYTHEMATOSUS | SSB, TPMT, SPHK1 | KCNH2 1707/4885MAPT 4226/4885HTT 4861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.