Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21887378 | 0.88 | KCNH2 (0.44) | MEN1KMT2AL3MBTL1TP53KCNH2 | |
| SCHEMBL21887781 | 0.88 | NPSR1 (0.43) | MEN1KMT2AL3MBTL1TP53HPGD | |
| SCHEMBL21887777 | 0.82 | MAPT (0.44) | L3MBTL1TP53HPGDSMN1; SMN2MAPT | |
| SCHEMBL24985048 | 0.82 | NPC1 (0.37) | MEN1KMT2AL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL21811164 | 0.81 | AKR1C3 (0.46) | MEN1KMT2AL3MBTL1TP53KCNH2 | |
| SCHEMBL30162010 | 0.79 | TYK2 (0.62) | — | |
| SCHEMBL21887371 | 0.79 | TYK2 (0.62) | — | |
| SCHEMBL21887375 | 0.77 | KDM4E (0.42) | L3MBTL1TP53HPGDSMN1; SMN2GAA | |
| SCHEMBL21887372 | 0.75 | TDP1 (0.44) | MEN1KMT2AL3MBTL1TP53GAA | |
| SCHEMBL31245714 | 0.73 | TYK2 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3849981-B1 | PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSORIASIS AND SYSTEMIC LUPUS ERYTHEMATOSUS | LILLY CO ELI (US) | 2023-02-01 | — | — | EP | disclosed |