Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.45 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.45 |
| ▸ | PI4KA | P42356 | 1/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29403530 | 1.00 | JAK2 (0.50) | JAK2HSP90AA1AURKAPRKACAADORA2A | |
| SCHEMBL21887563 | 0.80 | ASIC3 (0.49) | HSP90AA1PIK3CDPIK3CAPIK3CGPIP5K1C | |
| SCHEMBL17767937 | 0.80 | JAK2 (0.53) | JAK2HSP90AA1AURKAPRKACAADORA2A | |
| Hydrochloric Acid SCHEMBL22836886 | 0.78 | JAK2 (0.52) | JAK2HSP90AA1AURKAPRKACAADORA2A | |
| SCHEMBL21887464 | 0.77 | ASIC3 (0.47) | JAK2PIK3CDPIK3CAPIK3CGPIP5K1C | |
| SCHEMBL21819358 | 0.76 | JAK2 (0.50) | JAK2HSP90AA1AURKAPRKACAADORA2A | |
| SCHEMBL18770695 | 0.74 | KDM5B (0.44) | PIK3CDPIK3CAPIK3CGPIP5K1CPI4KA | |
| SCHEMBL29371998 | 0.74 | PIK3CD (0.52) | MAPTPIK3CDPIK3CAPIK3CGPIP5K1C | |
| SCHEMBL21876279 | 0.74 | PIK3CD (0.52) | MAPTPIK3CDPIK3CAPIK3CGPIP5K1C | |
| SCHEMBL20324964 | 0.73 | KDR (0.46) | JAK2KDM4EPIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020061112-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | METACRINE, INC. (US) | 2020-03-26 | — | — | WO | disclosed |