Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP2 | P42575 | 1/20 | 0.54 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.53 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.53 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 4/20 | 0.53 |
| ▸ | NAAA | Q02083 | 1/20 | 0.51 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.48 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21204263 | 0.87 | LPAR1 (0.55) | CASP2LPAR1LPAR2ENPP2FAAH | |
| SCHEMBL16639380 | 0.87 | LPAR1 (0.55) | CASP2LPAR1LPAR2ENPP2FAAH | |
| SCHEMBL21204364 | 0.87 | LPAR1 (0.55) | CASP2LPAR1LPAR2ENPP2FAAH | |
| SCHEMBL21204352 | 0.87 | LPAR1 (0.55) | CASP2LPAR1LPAR2ENPP2FAAH | |
| SCHEMBL26242295 | 0.86 | CASP2 (0.51) | CASP2LPAR1LPAR2ENPP2FAAH | |
| SCHEMBL17056238 | 0.85 | LPAR1 (0.71) | CASP2LPAR1LPAR2ENPP2FAAH | |
| SCHEMBL16640031 | 0.85 | LPAR1 (0.71) | CASP2LPAR1LPAR2ENPP2FAAH | |
| SCHEMBL18736049 | 0.85 | TSHR (0.68) | CASP2LPAR1LPAR2ENPP2FAAH | |
| SCHEMBL18735873 | 0.85 | TSHR (0.68) | CASP2LPAR1LPAR2ENPP2FAAH | |
| SCHEMBL27098303 | 0.85 | TSHR (0.68) | CASP2LPAR1LPAR2ENPP2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020061497-A1 | COMPOSITIONS AND METHODS FOR MODULATION OF LMNA EXPRESSION | IONIS PHARMACEUTICALS, INC. (US) | 2020-03-26 | — | — | WO | disclosed |