Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.69 |
| ▸ | USP2 | O75604 | 5/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2188924 | 1.00 | L3MBTL1 (0.69) | L3MBTL1USP2PAX8MAPTCA2 | |
| SCHEMBL12418067 | 1.00 | L3MBTL1 (0.69) | L3MBTL1USP2PAX8MAPTCA2 | |
| SCHEMBL2188914 | 1.00 | L3MBTL1 (0.69) | L3MBTL1USP2PAX8MAPTCA2 | |
| SCHEMBL12508089 | 1.00 | L3MBTL1 (0.69) | L3MBTL1USP2PAX8MAPTCA2 | |
| SCHEMBL17498012 | 0.94 | L3MBTL1 (0.67) | L3MBTL1USP2PAX8MAPTCA2 | |
| SCHEMBL17498014 | 0.94 | L3MBTL1 (0.67) | L3MBTL1USP2PAX8MAPTCA2 | |
| SCHEMBL17498016 | 0.94 | L3MBTL1 (0.67) | L3MBTL1USP2PAX8MAPTCA2 | |
| SCHEMBL17498010 | 0.94 | L3MBTL1 (0.67) | L3MBTL1USP2PAX8MAPTCA2 | |
| SCHEMBL17497925 | 0.86 | L3MBTL1 (0.75) | L3MBTL1USP2PAX8MAPTCA2 | |
| SCHEMBL17497402 | 0.86 | L3MBTL1 (0.75) | L3MBTL1USP2PAX8MAPTCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160046590-A1 | SONIC HEDGEHOG MODULATORS | MASSACHUSETTS INST TECHNOLOGY (US) | 2016-02-18 | — | — | US | disclosed |
| US-20160046590-A1 | SONIC HEDGEHOG MODULATORS | MASSACHUSETTS INST TECHNOLOGY (US) | 2016-02-18 | — | — | US | disclosed |
| US-8530456-B2 | Sonic hedgehog modulators | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-09-10 | — | — | US | disclosed |
| US-8530456-B2 | Sonic hedgehog modulators | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-09-10 | — | — | US | disclosed |
| US-20110172233-A1 | SONIC HEDGEHOG MODULATORS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172233-A1 | SONIC HEDGEHOG MODULATORS | SHH, GLI1, SMO | L3MBTL1 1133/4885USP2 1861/4885PAX8 190/4885 |
| US-20160046590-A1 | SONIC HEDGEHOG MODULATORS | SHH, GLI1, SMO | L3MBTL1 188/4885USP2 234/4885PAX8 339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.