Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 7/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2188257 | 0.86 | HIF1A (0.50) | HIF1APPARAHDAC8CA1CA2 | |
| SCHEMBL2188031 | 0.86 | HIF1A (0.50) | HIF1APPARAHDAC8CA1CA2 | |
| SCHEMBL2190706 | 0.84 | HIF1A (0.55) | HIF1APPARASLC7A5HDAC8HDAC11 | |
| SCHEMBL17604932 | 0.78 | PPARA (0.61) | PPARA | |
| SCHEMBL2189778 | 0.78 | HDAC8 (0.58) | HIF1APPARAHDAC8HDAC11CA1 | |
| SCHEMBL2187378 | 0.76 | PPARA (0.49) | PPARAFNTAFNTBPGGT1BFFAR1 | |
| SCHEMBL2185832 | 0.76 | PPARA (0.58) | PPARASLC7A5FFAR1 | |
| SCHEMBL13662621 | 0.76 | PPARA (0.49) | HIF1APPARASLC7A5HDAC8HDAC11 | |
| SCHEMBL13641732 | 0.75 | MEN1 (0.52) | HIF1APPARASLC7A5FFAR1 | |
| SCHEMBL13605111 | 0.74 | CA1 (0.57) | HIF1APPARASLC7A5CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | disclosed |