SCHEMBL21890809

SCHEMBL21890809

c1ccc2c(c1)nc1c3cc4sc5ccccc5c4cc3c3cc4sc5ccccc5c4cc3n21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 10/20 0.43
MAPT P10636 6/20 0.43
HSD17B10 Q99714 4/20 0.43
LMNA P02545 4/20 0.43
TP53 P04637 3/20 0.43
POLB P06746 2/20 0.43
HPGD P15428 8/20 0.43
ALDH1A1 P00352 7/20 0.43
KMT2A Q03164 4/20 0.41
MEN1 O00255 2/20 0.41
SMN1; SMN2 Q16637 4/20 0.39
RAB9A P51151 3/20 0.37
NPC1 O15118 3/20 0.37
GPR3 P46089 1/20 0.37
NFKB1 P19838 1/20 0.35
NFKB2 Q00653 1/20 0.35
RELA Q04206 1/20 0.35
BCL2 P10415 1/20 0.35
GAA P10253 1/20 0.35
HIF1A Q16665 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21890188 0.97 KDM4E (0.43) KDM4EMAPTHSD17B10LMNATP53
SCHEMBL21298051 0.95 KDM4E (0.42) KDM4EMAPTHSD17B10LMNATP53
SCHEMBL22223041 0.93 KDM4E (0.44) KDM4EMAPTHSD17B10LMNATP53
SCHEMBL21298319 0.92 KDM4E (0.42) KDM4EMAPTHSD17B10LMNATP53
SCHEMBL24292192 0.91 KDM4E (0.44) KDM4EMAPTHSD17B10LMNATP53
SCHEMBL21890627 0.90 KDM4E (0.39) KDM4EMAPTHSD17B10LMNATP53
SCHEMBL21890630 0.90 KDM4E (0.39) KDM4EMAPTHSD17B10LMNATP53
SCHEMBL21890345 0.90 KDM4E (0.39) KDM4EMAPTHSD17B10LMNATP53
SCHEMBL21890841 0.90 KDM4E (0.39) KDM4EMAPTHSD17B10LMNATP53
SCHEMBL21890185 0.89 KDM4E (0.36) KDM4EMAPTHSD17B10LMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230068759-A1 DONOR-ACCEPTOR TYPE THERMALLY ACTIVATED DELAYED FLUORESCENT MATERIALS BASED ON IMIDAZO[1,2-F]PHENANTHRIDINE AND ANALOGUES ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2023-03-02 US disclosed
US-20200227656-A1 DONOR-ACCEPTOR TYPE THERMALLY ACTIVATED DELAYED FLUORESCENT MATERIALS BASED ON IMIDAZO[1,2-F]PHENANTHRIDINE AND ANALOGUES ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2020-07-16 US disclosed
US-10615349-B2 Donor-acceptor type thermally activated delayed fluorescent materials based on imidazo[1,2-F]phenanthridine and analogues ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2020-04-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200227656-A1 DONOR-ACCEPTOR TYPE THERMALLY ACTIVATED DELAYED FLUORESCENT MATERIALS BASED ON IMIDAZO[1,2-F]PHENANTHRIDINE AND ANALOGUES SUN2, STAU1, HELZ KDM4E 4206/4885MAPT 2512/4885HSD17B10 3254/4885
US-20230068759-A1 DONOR-ACCEPTOR TYPE THERMALLY ACTIVATED DELAYED FLUORESCENT MATERIALS BASED ON IMIDAZO[1,2-F]PHENANTHRIDINE AND ANALOGUES SUN2, STAU1, HELZ KDM4E 4206/4885MAPT 2512/4885HSD17B10 3254/4885
US-10615349-B2 Donor-acceptor type thermally activated delayed fluorescent materials based on imidazo[1,2-F]phenanthridine and analogues SUN2, STAU1, HELZ KDM4E 4206/4885MAPT 2512/4885HSD17B10 3254/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.