Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 4/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.55 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.53 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.35 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | F2R | P25116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186987 | 0.80 | CSNK1E (0.81) | CSNK1ECSNK1DCSNK1G3SLC40A1NPC1 | |
| SCHEMBL2189066 | 0.79 | CSNK1E (0.69) | CSNK1ECSNK1DCSNK1G3SLC40A1NPC1 | |
| SCHEMBL2189072 | 0.78 | CSNK1E (0.58) | CSNK1ECSNK1DCSNK1G3SLC40A1NPC1 | |
| SCHEMBL420828 | 0.78 | CSNK1E (0.59) | CSNK1ECSNK1DCSNK1G3NPC1RAB9A | |
| SCHEMBL15541991 | 0.74 | CSNK1E (0.60) | CSNK1ECSNK1DCSNK1G3NPC1RAB9A | |
| SCHEMBL28775420 | 0.72 | CSNK1E (0.84) | CSNK1ECSNK1DCSNK1G3NPC1RAB9A | |
| SCHEMBL2186882 | 0.70 | CSNK1E (0.65) | CSNK1ECSNK1DCSNK1G3SLC40A1NPC1 | |
| SCHEMBL2186444 | 0.70 | CSNK1E (0.79) | CSNK1ECSNK1DCSNK1G3NPC1RAB9A | |
| SCHEMBL2187181 | 0.70 | CSNK1E (0.56) | CSNK1ECSNK1DCSNK1G3SLC40A1NPC1 | |
| SCHEMBL15541229 | 0.70 | SMN1; SMN2 (0.64) | CSNK1ECSNK1DCSNK1G3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |