Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 3/20 | 0.59 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.59 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.52 |
| ▸ | KCNK3 | O14649 | 4/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.47 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.46 |
| ▸ | F2R | P25116 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15541991 | 0.89 | CSNK1E (0.60) | CSNK1ECSNK1DCSNK1G3KCNK3KCNK9 | |
| SCHEMBL15541229 | 0.84 | SMN1; SMN2 (0.64) | CSNK1ECSNK1DCSNK1G3F2RNPC1 | |
| SCHEMBL2186987 | 0.80 | CSNK1E (0.81) | CSNK1ECSNK1DCSNK1G3NPC1RAB9A | |
| SCHEMBL2187390 | 0.80 | CSNK1E (0.53) | CSNK1ECSNK1DCSNK1G3CYP2C9KCNK3 | |
| SCHEMBL2187471 | 0.79 | CSNK1E (0.57) | CSNK1ECSNK1DCSNK1G3KCNK3KCNK9 | |
| SCHEMBL2189072 | 0.78 | CSNK1E (0.58) | CSNK1ECSNK1DCSNK1G3KCNK3KCNK9 | |
| SCHEMBL419064 | 0.78 | ALDH1A1 (0.58) | CYP2C9NPC1RAB9AMEN1KMT2A | |
| SCHEMBL2189173 | 0.78 | CSNK1E (0.55) | CSNK1ECSNK1DCSNK1G3KCNK3KCNK9 | |
| SCHEMBL2187098 | 0.77 | CSNK1E (0.51) | CSNK1ECSNK1DCSNK1G3CYP2C9KDM4E | |
| SCHEMBL2187360 | 0.77 | CSNK1E (0.49) | CSNK1ECSNK1DCSNK1G3ANO1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022068-A1 | NOVEL HETEROCYCLIC NF-kB INHIBITORS | 4SC AG (DE) | 2012-01-26 | — | — | US | disclosed |
| US-20100267717-A1 | Novel Heterocyclic NF-kB Inhibitors | 4SC AG (DE) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267717-A1 | Novel Heterocyclic NF-kB Inhibitors | NFKB2, NFKBIA, NFRKB | CSNK1E 142/4885CSNK1D 188/4885CSNK1G3 342/4885 |
| US-20120022068-A1 | NOVEL HETEROCYCLIC NF-kB INHIBITORS | NFKB2, NFKBIA, NFRKB | CSNK1E 142/4885CSNK1D 188/4885CSNK1G3 342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.