Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 3/20 | 0.34 |
| ▸ | SGMS1 | Q86VZ5 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 2/20 | 0.33 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2189359 | 0.89 | CNR1 (0.33) | CNR1MAPTTP53RAF1TRPV1 | |
| SCHEMBL4387708 | 0.78 | TRPV1 (0.44) | CNR1MAPTTP53RAF1TRPV1 | |
| SCHEMBL283213 | 0.77 | TRPV1 (0.58) | CNR1MAPTTP53TRPV1SGMS1 | |
| SCHEMBL2171624 | 0.76 | CNR1 (0.51) | CNR1MAPTTP53ALDH1A1GAA | |
| SCHEMBL2174484 | 0.76 | IGF1R (0.49) | MAPTTP53TRPV1SLC2A1GAA | |
| SCHEMBL2186611 | 0.75 | TRPV1 (0.48) | MAPTTP53TRPV1SGMS1IGF1R | |
| SCHEMBL4392406 | 0.75 | ALDH1A1 (0.43) | MAPTALDH1A1GAAKMT2ASMN1; SMN2 | |
| SCHEMBL5668846 | 0.75 | IGF1R (0.47) | MAPTGAAIGF1RRAB9AKMT2A | |
| SCHEMBL4383724 | 0.75 | ALDH1A1 (0.43) | MAPTALDH1A1GAAKMT2ASMN1; SMN2 | |
| SCHEMBL4395355 | 0.75 | ALDH1A1 (0.43) | MAPTALDH1A1GAAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973061-B2 | Anaplastic lymphoma kinase modulators and methods of use | EXELIXIS, INC. (US) | 2011-07-05 | — | — | US | claimed |