Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | GRM6 | O15303 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | XIAP | P98170 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL496791 | 0.84 | KDM4E (0.71) | ALDH1A1HSD17B10SMN1; SMN2KDM4EHPGD | |
| SCHEMBL80459 | 0.80 | ALOX5 (0.61) | ALDH1A1HSD17B10SMN1; SMN2KDM4EHPGD | |
| SCHEMBL27854288 | 0.80 | ALOX5 (0.61) | ALDH1A1HSD17B10SMN1; SMN2KDM4EHPGD | |
| SCHEMBL2185647 | 0.79 | ALOX5 (0.49) | ALDH1A1HSD17B10SMN1; SMN2KDM4EHPGD | |
| SCHEMBL3643609 | 0.79 | ALOX5 (0.46) | ALDH1A1HSD17B10SMN1; SMN2KDM4EHPGD | |
| SCHEMBL3643611 | 0.79 | ALOX5 (0.46) | ALDH1A1HSD17B10SMN1; SMN2KDM4EHPGD | |
| SCHEMBL28787242 | 0.78 | ALOX5 (0.48) | ALDH1A1HSD17B10SMN1; SMN2KDM4EHPGD | |
| SCHEMBL27784717 | 0.78 | ALOX5 (0.48) | ALDH1A1HSD17B10SMN1; SMN2KDM4EHPGD | |
| SCHEMBL27806743 | 0.78 | ALOX5 (0.48) | ALDH1A1HSD17B10SMN1; SMN2KDM4EHPGD | |
| SCHEMBL3646674 | 0.78 | ALOX5 (0.44) | ALDH1A1HSD17B10SMN1; SMN2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973061-B2 | Anaplastic lymphoma kinase modulators and methods of use | EXELIXIS, INC. (US) | 2011-07-05 | — | — | US | disclosed |
| US-20090186905-A1 | ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2009-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186905-A1 | ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE | ALK, BCL3, MCL1 | ALDH1A1 1466/4885HSD17B10 3125/4885SMN1; SMN2 4564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.