Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14652652 | 0.82 | SMN1; SMN2 (0.36) | SMN1; SMN2ALOX15PARP1ALDH1A1TSHR | |
| SCHEMBL20861256 | 0.74 | SMN1; SMN2 (0.45) | SMN1; SMN2ALOX15PARP1ALDH1A1TSHR | |
| SCHEMBL11593915 | 0.71 | SMN1; SMN2 (0.62) | SMN1; SMN2ALOX15PARP1ALDH1A1TSHR | |
| SCHEMBL18506621 | 0.69 | SMN1; SMN2 (0.59) | SMN1; SMN2ALOX15PARP1ALDH1A1TSHR | |
| SCHEMBL18506623 | 0.69 | SMN1; SMN2 (0.59) | SMN1; SMN2ALOX15PARP1ALDH1A1TSHR | |
| SCHEMBL24169930 | 0.64 | — | — | |
| SCHEMBL7359596 | 0.63 | MEN1 (0.40) | SMN1; SMN2PARP1ALDH1A1TSHRKDM4E | |
| SCHEMBL3858956 | 0.62 | SMN1; SMN2 (0.58) | SMN1; SMN2ALOX15PARP1ALDH1A1TSHR | |
| SCHEMBL11128515 | 0.61 | SMN1; SMN2 (0.41) | SMN1; SMN2ALOX15PARP1ALDH1A1TSHR | |
| SCHEMBL19212160 | 0.61 | ALDH1A1 (0.32) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081636-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2020-04-23 | — | — | WO | disclosed |