Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 18/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21754321 | 0.88 | AHR (0.49) | AHRTLR7CYP11B1CYP11B2 | |
| SCHEMBL24408393 | 0.86 | AHR (0.40) | AHRTLR7CYP11B1CYP11B2 | |
| SCHEMBL21754187 | 0.79 | CYP11B2 (0.39) | AHRTLR7CYP11B1CYP11B2 | |
| SCHEMBL21899872 | 0.79 | CYP11B1 (0.35) | AHRTLR7CYP11B1CYP11B2 | |
| SCHEMBL21899137 | 0.78 | AHR (0.36) | AHRCYP11B2 | |
| SCHEMBL21899764 | 0.77 | TLR7 (0.33) | AHRTLR7CYP11B1CYP11B2 | |
| SCHEMBL23443604 | 0.75 | CSNK1D (0.34) | AHRTLR7CYP11B1CYP11B2 | |
| SCHEMBL21899187 | 0.75 | AHR (0.37) | AHRCYP11B1CYP11B2 | |
| SCHEMBL23444315 | 0.74 | CYP11B2 (0.36) | AHRCYP11B1CYP11B2 | |
| SCHEMBL20558149 | 0.74 | AHR (0.49) | AHRTLR7CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081636-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2020-04-23 | — | — | WO | disclosed |