Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23096885 | 0.77 | DHODH (0.39) | HPGDALDH1A1TSHRMAPK1SLC6A2 | |
| SCHEMBL13865278 | 0.76 | HSD17B10 (0.50) | HPGDHSD17B10ALDH1A1TSHRTDP1 | |
| SCHEMBL10804395 | 0.75 | HSD17B10 (0.39) | HPGDHSD17B10ALDH1A1TSHRTDP1 | |
| SCHEMBL5703437 | 0.74 | — | — | |
| SCHEMBL20403588 | 0.71 | KMT2A (0.47) | ALDH1A1TSHRPTGS2LMNAGAA | |
| SCHEMBL3916337 | 0.70 | HSD17B10 (0.55) | HPGDHSD17B10ALDH1A1TSHRTDP1 | |
| SCHEMBL13039964 | 0.69 | CYP2D6 (0.50) | HPGDHSD17B10ALDH1A1L3MBTL1ALOX15 | |
| Diphenylamine SCHEMBL1691353 | 0.69 | HSD17B10 (0.80) | HPGDHSD17B10ALDH1A1TSHRTDP1 | |
| Diphenylamine SCHEMBL8119680 | 0.69 | HSD17B10 (0.80) | HPGDHSD17B10ALDH1A1TSHRTDP1 | |
| Diphenylamine SCHEMBL27671770 | 0.69 | HSD17B10 (0.80) | HPGDHSD17B10ALDH1A1TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081636-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2020-04-23 | — | — | WO | disclosed |